ORCID ID: http://orcid.org/0000-0003-4247-1209
* = equal contributions

[8]
Blake K.S.*, Gillespie V., Xue Y.P., Fishbein S.R.S., Tolia N.H., Wencewicz T.A., Dantas G. The tetracycline resistome was shaped by selection for specific resistance mechanisms by each antibiotic generation. Under review.

[7]
Blake K.S.*, Kumar H.*, Loganathan A.*, Williford E.E.*, Diorio-Toth L., Xue Y.P., Tang W.K., Campbell T., Chong D.D., Angtuaco S., Wencewicz T.A., Tolia N.H., Dantas G. Sequence-structure-function characterization of the emerging tetracycline destructases family of antibiotic resistance enzymes. Communications Biology. 2024 Mar 16;7(1):336. doi: 10.1038/s42003-024-06023-w. PMID: 38493211. [PDF]

[6]
Blake K.S.*, Schwartz D.J.*, Paruthiyil S.*, Wang B., Ning J., Isidean S.D., Burns D.S., Whiteson H., Lalani T., Fraser J.A., Connor P., Troth T., Porter C.K., Tribble D.R., Riddle M.S., Gutiérrez R.L., Simons M.P., Dantas G. Gut microbiome and antibiotic resistance effects during travelers’ diarrhea treatment and prevention. mBio. 2023 Dec 12:e0279023. doi: 10.1128/mbio.02790-23. PMID: 38085102. [PDF]

[5]
Kumar H., Williford E.E., Blake K.S., Virgin-Downey B., Dantas G., Wencewicz T.A., Tolia N.H. Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases. Communications Biology. 2023 Apr 17; 6(1):423 doi: https://doi.org/10.1038/s42003-023-04792-4. PMID: 37062778. [PDF]

[4]
Williford E.E., DeAngelo C.M., Blake K.S., Kumar H., Lam K.K., Jones K.V., Tolia N.H., Dantas G., Wencewicz T.A. Structure-based design of bisubstrate tetracycline destructase inhibitors that block flavin redox cycling. Journal of Medicinal Chemistry. 2023 Mar 06; 66(6): 3917-3933. doi: 10.1021/acs.jmedchem.2c01629. PMID: 36877173.  [PDF]

[3]
Talat A.*, Blake K.S.*, Dantas G., Khan A.U. Metagenomic insight into microbiome and antibiotic resistance genes of high clinical concern in urban and rural hospital wastewater of Northern India origin: a major reservoir of antimicrobial resistance. Microbiology Spectrum. 2023 Feb 14;11(2):e0410222. doi: 10.1128/spectrum.04102-22. PMID: 36786639. [PDF]

[2]
Boolchandani M., Blake K.S., Tilley D.H., Cabada M.M., Schwartz D.J., Patel S.,  Morales M.L., Meza R., Soto G., Isidean S.D., Porter C.K., Simons M.P., Dantas G. Impact of international travel and diarrhea on gut microbiome and resistome dynamics. Nature Communications. 2022 Dec 05;13(1):7485. doi: 10.1038/s41467-022-34862-w. PMID: 36470885. [PDF]

[1]
Blake K.S.*, Choi J.*, Dantas G. Approaches for characterizing and tracking hospital-associated multidrug-resistant bacteria. Cellular and Molecular Life Sciences. 2021 Feb 13; 78:2585-2606. doi: 10.1007/s00018-020-03717-2. PMID: 33582841. [PDF]